Key result
PEAR1 SNPs linked to altered prasugrel pharmacodynamics in healthy Han Chinese subjects.
Why the study?
Do PEAR1 genetic polymorphisms influence the pharmacodynamics of prasugrel in healthy Han Chinese subjects?
Observational
Do PEAR1 genetic polymorphisms influence the pharmacodynamics of prasugrel in healthy Han Chinese subjects?
Polymorphisms in the PEAR1 gene may significantly influence the pharmacodynamic response to prasugrel, highlighting a potential pharmacogenetic factor in antiplatelet therapy.
PEAR1 SNPs may influence prasugrel response in healthy Han Chinese; hypothesis-generating, requires validation in patients before any practice implications.
AIM: The present study aimed to investigate PEAR1 genetic polymorphisms and pharmacogenetic variability in the pharmacodynamics of prasugrel, a new oral antiplatelet agent, in healthy Han Chinese subjects. PATIENTS & METHODS: The inhibition of adenosine diphosphate-induced platelet aggregation was measured pre- and post-administration using the VerifyNow(®) P2Y12 assay. The genetic sequence of PEAR1 exons and previously reported SNPs in the PEAR1 gene were investigated. RESULTS: A total of 28 variations were identified in PEAR1. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics. CONCLUSION: Further studies with larger sample sizes are recommended to explore the clinical importance of PEAR1 SNPs in prasugrel and other antiplatelet therapies. Original submitted 18 December 2012; Revision submitted 26 April 2013.
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Xiang et al. (2013) conducted an observational in Healthy. PEAR1 genetic polymorphisms was evaluated on Inhibition of adenosine diphosphate-induced platelet aggregation. PEAR1 SNPs in two regions (rs3737224 to rs822442 and rs1214331 to rs12566888) likely play important roles in prasugrel pharmacodynamics among healthy Han Chinese subjects.
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