Key result
Single-molecule fluorescence polarization reveals formin mDia1 undergoes helical rotation along F-actin during processive elongation.
Demonstrated that helical rotation is an intrinsic property of formins during actin filament elongation.
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Establishes helical rotation as intrinsic to formins; leaves open relevance to actin dynamics in cardiovascular cells.
Mizuno et al. (2010) studied this question. Single-molecule fluorescence polarization was evaluated on Helical rotation of the formin mDia1. Single-molecule fluorescence polarization demonstrated that the formin mDia1 undergoes helical rotation along the axis of the double helical F-actin structure during processive elongation.
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