What question did this study set out to answer?

To develop a synthetic method for assembling multi-substituted triarylbenzenes using tandem aryne-mediated couplings of aryl Grignards with polyhalobenzenes.

July 1, 1988The Journal of Organic Chemistry

Synthesis of triarylbenzenes via tandem aryne reactions of aryl Grignards with polyhalobenzenes

View Full Paper

Ask AI

Bookmark

Authors

TGTirthankar GhoshRamakrishna Mission Vivekananda Educational and Research Institute HHHarold HartGifu Pharmaceutical University

Discussion

Member takes

Implication

Experimental study demonstrates the synthesis of triarylbenzenes using aryl Grignard reagents and polyhalobenzenes, highlighting an efficient tandem aryne pathway for complex aromatic frameworks.

Key Points

To develop a synthetic method for assembling multi-substituted triarylbenzenes using tandem aryne-mediated couplings of aryl Grignards with polyhalobenzenes.
Treated polyhalobenzene substrates with aryl Grignard reagents to generate transient aryne intermediates in situ.
Facilitated sequential nucleophilic additions and subsequent aryne generations in a single tandem reaction pathway.
Achieved efficient construction of triarylbenzene architectures through multiple consecutive carbon-carbon bond formations.
Demonstrated that polyhalobenzenes serve as effective multivalent precursors for tandem aryne generation when coupled with organomagnesium reagents.

Cite This Study

Ghosh et al. (1988) studied this question.

synapsesocial.com/papers/6aa37949fd19ae9969b144d9 https://doi.org/10.1021/jo00250a026

View Full Paper

Ask AI

Bookmark

Implication

Experimental study demonstrates the synthesis of triarylbenzenes using aryl Grignard reagents and polyhalobenzenes, highlighting an efficient tandem aryne pathway for complex aromatic frameworks.

Synthesis of triarylbenzenes via tandem aryne reactions of aryl Grignards with polyhalobenzenes

Discussion

Member takes

Implication

Key Points

Cite This Study

Synthesis of triarylbenzenes via tandem aryne reactions of aryl Grignards with polyhalobenzenes

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider