Key result
Postnatal cardiac maturation entails metabolic and structural reprogramming that reverts to a fetal state during the development of pathological cardiac hypertrophy and heart failure.
Understanding the transcriptional control of cardiac maturation and its reversion to a fetal state during pathological hypertrophy may provide new translational avenues for treating heart failure.
May inform HF therapies targeting metabolic reversion; leaves open whether modulating fetal reprogramming improves outcomes.
The heart undergoes a dynamic maturation process following birth, in response to a wide range of stimuli, including both physiological and pathological cues. This process entails substantial re-programming of mitochondrial energy metabolism coincident with the emergence of specialized structural and contractile machinery to meet the demands of the adult heart. Many components of this program revert to a more "fetal" format during development of pathological cardiac hypertrophy and heart failure. In this review, emphasis is placed on recent progress in our understanding of the transcriptional control of cardiac maturation, encompassing the results of studies spanning from in vivo models to cardiomyocytes derived from human stem cells. The potential applications of this current state of knowledge to new translational avenues aimed at the treatment of heart failure is also addressed.
No takes yet. Share an insight, caveat, or question.
Sakamoto et al. (2023) studied this question. Postnatal cardiac maturation entails metabolic and structural reprogramming that reverts to a fetal state during the development of pathological cardiac hypertrophy and heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: