Key result
PGC1/PPAR signaling coordinates postnatal cardiomyocyte maturation, including cellular hypertrophy and contractility, through downstream effectors YAP1 and SF3B2.
Why the study?
How individual newborn cardiomyocytes acquire multiple aspects of the mature phenotype remains poorly understood due to challenges isolating single postnatal or adult myocytes.
Does PGC1/PPAR signaling drive cardiomyocyte maturation via YAP1 and SF3B2?
Does PGC1/PPAR signaling drive cardiomyocyte maturation via YAP1 and SF3B2?
PGC1/PPAR signaling is identified as a multifaceted regulator controlling cardiomyocyte maturation through YAP1 and SF3B2, providing a single-cell roadmap of heterogeneous transitions.
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Caution against clinical translation from animal data alone; leaves open human relevance of PGC1/PPAR maturation pathways.
Murphy et al. (2021) studied Cardiomyocyte maturation. PGC1/PPAR activation vs. Control or PGC1-deficient cells was evaluated on Cardiomyocyte maturation (hypertrophy, contractility, and mitochondrial activity). PGC1/PPAR signaling coordinates postnatal cardiomyocyte maturation, including cellular hypertrophy and contractility, through downstream effectors YAP1 and SF3B2.
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