Key result
Contractile proteins are suggested to play a critical role in platelet function, including maintaining normal disc shape, pseudopod formation, secretion, aggregation, and contraction.
Contractile proteins are suggested to play a critical role in platelet function, including shape maintenance, secretion, aggregation, and contraction during hemostasis and thrombosis.
Highlights potential contractile protein targets in platelet thrombosis; leaves open clinical translation pending interventional studies.
Platelets are anucleate, disc-shaped blood cells with a diameter of about 3 microns in humans. They play critical roles in the related processes of hemeostasis and thrombosis. On stimulation by diverse agents, such as thrombin, ADP, epinephrine, and collagen, they undergo a sequence of profound changes. These changes include pseudopod formation, centralization of granules, secretion of specific constituents, aggregation, and finally contraction of the aggregated platelet. When the contracted platelet aggregate adheres to the exposed surfaces of a severed vessel, it is referred to as a platelet plug and it represents the primary defense against the loss of blood. When it forms on the diseased lining of an intact blood vessel, it is referred to as a thrombus and may completely block blood flow. For each of the above processes in platelet function, as well as for maintaining the normal disc shape, a role of contractile proteins has been suggested.
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Abramowitz et al. (1973) conducted a review in Platelet function and thrombosis. Contractile proteins was evaluated. Contractile proteins are suggested to play a critical role in platelet function, including maintaining normal disc shape, pseudopod formation, secretion, aggregation, and contraction.
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