Key result
Moderate-intensity aerobic exercise before glucose ingestion suppressed the increase in leg arterial stiffness observed after glucose ingestion in the low-intensity trial.
Why the study?
Does moderate-intensity aerobic exercise prevent increases in arterial stiffness after glucose ingestion in healthy young men compared to low-intensity exercise?
RCT (n=10)
Randomized crossover
Does moderate-intensity aerobic exercise prevent increases in arterial stiffness after glucose ingestion in healthy young men compared to low-intensity exercise?
p-value: p=<0.05
Moderate-intensity aerobic exercise prior to glucose ingestion suppresses the acute increase in leg arterial stiffness typically seen after glucose loading.
Moderate-intensity pre-glucose exercise prevents post-ingestion leg arterial stiffness rise in young men; extends evidence on exercise timing for acute vascular protection.
Arterial stiffness increases after glucose ingestion. Acute low- and moderate-intensity aerobic exercise decreases arterial stiffness. However, the acute effects of 30 min of cycling at low- and moderate-intensity [25% (LE trial) and 65% (ME trial) peak oxygen uptake, respectively] on arterial stiffness at 30, 60 and 120 min of a postexercise glucose ingestion. Ten healthy young men (age, 22·4 ± 0·5 years) performed LE and ME trials on separate days in a randomized controlled crossover fashion. Carotid-femoral (aortic) pulse wave velocity (PWV), femoral-ankle (leg) PWV, carotid augmentation index (AIx) and carotid blood pressure (BP) (applanation tonometry), brachial and ankle BP (oscillometric device), heart rate (HR) (electrocardiography), blood glucose (UV-hexokinase method) and blood insulin (CLEIA method) levels were measured at before (baseline) and at 30, 60 and 120 min after the 75-g OGTT. Leg PWV, ankle pulse pressure and BG levels significantly increased from baseline after the 75-g OGTT in the LE trial (P<0·05), but not in the ME trial. Insulin levels and HR significantly increased from baseline after the 75-g OGTT in both trials (P<0·05). Aortic PWV, carotid AIx, brachial BP and carotid BP did not change from baseline after the 75-g OGTT in both trials. The present findings indicate that aerobic exercise at moderate intensity before glucose ingestion suppresses increases leg arterial stiffness after glucose ingestion.
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Kobayashi et al. (2016) conducted an RCT in Healthy (n=10). Moderate-intensity aerobic exercise vs. Low-intensity aerobic exercise (30 min cycling at 25% peak oxygen uptake) was evaluated on Leg pulse wave velocity (PWV) after 75-g OGTT (p=<0.05). Moderate-intensity aerobic exercise before glucose ingestion suppressed the increase in leg arterial stiffness observed after glucose ingestion in the low-intensity trial.
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