Key result
Economical Indian DES show no difference in 1-year major events versus imported stents.
Why the study?
Does the use of economical Indian DES compared to imported DES result in similar rates of all-cause mortality, stent thrombosis, and revascularization in patients undergoing coronary stenting?
Observational (n=3,395)
Yes
Does the use of economical Indian DES compared to imported DES result in similar rates of all-cause mortality, stent thrombosis, and revascularization in patients undergoing coronary stenting?
Economical Indian drug eluting stents demonstrated comparable one-year clinical outcomes to well-evaluated imported stents in a prospective registry.
Similar one-year outcomes with imported versus indigenous DES; hypothesis-generating but should not change practice without RCTs.
We compared one-year clinical outcomes of different drug eluting stents (DES) used in a prospective observation registry maintained in two hospitals over three years. The primary endpoint was combination of all-cause mortality, stent thrombosis and revascularization. There was no significant difference among different DES. We grouped DES into well-evaluated Imported DES (Imported group), which used to be expensive prior to price control and economical Indian DES (Indigenous group) that lack supportive clinical trials. One-year follow-up data was available in 99% of Indigenous group (n=1856) and 98.5% of Imported group (n=1539). After propensity score matching, there were 1310 matched pairs. There was no significant difference between two groups in the primary end-point or each of the components.
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Sastry et al. (2018) conducted an observational in Coronary artery disease requiring drug-eluting stents (n=3,395). Economical Indian drug-eluting stents vs. Imported drug-eluting stents was evaluated on Combination of all-cause mortality, stent thrombosis and revascularization. Economical Indian drug-eluting stents showed no significant difference in one-year all-cause mortality, stent thrombosis, and revascularization compared to imported stents.
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