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Acinar cell membrane potentials were measured by intracellular micro-electrode recording from isolated segments of mouse pancreas. At the normal resting potential (r. p.) of -40 mV a short lasting pulse of local acetylcholine stimulation (micro-iontophoresis) evoked a monophasic depolarization. At relatively low r. p. biphasic potential changes (depolarization - hyperpolarization) were observed. Strophanthin-G (1 mM) immediately reduced r. p., but had no effect on the secondary hyperpolarization.
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Nishiyama et al. (1975) studied this question.
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