Key result
Highest versus lowest quartile of serum elastase activity was associated with a lower 4-year occurrence of carotid plaques (12.2% vs 24.6%; OR 0.40; 95% CI 0.23-0.70; P<0.001).
Why the study?
Are serum elastase activity and serum elastase inhibitors associated with the occurrence of carotid atherosclerotic plaques in subjects free of coronary heart disease and stroke?
Population
859 subjects free of coronary heart disease and stroke, age 59 to 71 years
Comparison
Serum elastase activity and serum elastase… vs Comparison across quartiles
Design
Cohort
Follow-up
4 years
Authors
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Serum elastase activity was associated with lower carotid plaque incidence; leaves open whether it is a modifiable target or biomarker only.
Cohort (n=859)
Are serum elastase activity and serum elastase inhibitors associated with the occurrence of carotid atherosclerotic plaques in subjects free of coronary heart disease and stroke?
Odds Ratio: 0.4 (95% CI 0.23–0.7)
Absolute Event Rate: 12.2% vs 24.6%
p-value: p=<0.001
Low serum elastase activity and high serum elastase inhibitors are strongly and independently associated with an increased 4-year risk of carotid plaque occurrence.
Zureik et al. (2002) conducted a cohort in Carotid atherosclerotic plaques (n=859). Serum elastase activity (highest quartile) vs. Lowest quartile of serum elastase activity was evaluated on Occurrence of carotid plaques (OR 0.40, 95% CI 0.23-0.70, p=<0.001). Highest versus lowest quartile of serum elastase activity was associated with a lower 4-year occurrence of carotid plaques (12.2% vs 24.6%; OR 0.40; 95% CI 0.23-0.70; P<0.001).
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