Key result
Nalbuphine PCA at 2 or 3 mg/ml reduces postoperative pain and demands vs 1 mg/ml.
Why the study?
Does higher concentration nalbuphine (4 or 6 mg/ml) via PCA improve postoperative pain compared to 2 mg/ml in patients after total knee replacement?
Population
75 patients after total knee replacement
Comparison
Intravenous nalbuphine via patient-controlled… vs Intravenous nalbuphine via PCA at 2 mg/ml
Design
RCT, double-blind
Follow-up
48 hours
Authors
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Supports 2-3 mg/ml nalbuphine PCA dosing after TKR; extends concentration-response data for postoperative analgesia.
RCT (n=60)
Double-blind
Randomized
No
Does higher concentration nalbuphine (4 or 6 mg/ml) via PCA improve postoperative pain compared to 2 mg/ml in patients after total knee replacement?
p-value: p=<0.05
Higher concentrations of nalbuphine (4 or 6 mg/ml) via PCA provide better postoperative pain relief after total knee replacement compared to 2 mg/ml, though side effects like nausea and sedation require monitoring.
Kim et al. (2001) conducted an RCT in Postoperative pain after total knee replacement (n=60). Nalbuphine vs. Nalbuphine 1 mg/ml via PCA was evaluated on Visual analog scale (VAS) scores for pain at rest and movement over 48 hours (p=<0.05). Intravenous patient-controlled analgesia with 2 mg/ml or 3 mg/ml nalbuphine significantly reduced postoperative pain scores and PCA demands over 48 hours compared to 1 mg/ml nalbuphine after total knee replacement.
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