Key result
Subcutaneous nalbuphine delays first analgesic request by ~7.5 hours vs epidural analgesia after abdominal surgery.
Why the study?
Epidural analgesia is standard for pain control in major abdominal surgeries, but nalbuphine may offer effective analgesia with fewer side effects.
Does subcutaneous nalbuphine delay the time for the first postoperative analgesic request compared to epidural analgesia in adults undergoing open abdominal surgery?
Population
130 adult patients ASA class I or II aged 20-60 years undergoing open abdominal surgery
Comparison
Subcutaneous nalbuphine (0.15 mg/kg) vs epidural analgesia with bupivacaine 0.25% + fentanyl 100 mcg
Design
Randomized controlled trial, single-blind, two equal groups
Follow-up
24 postoperative hours
Authors
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Supports subcutaneous nalbuphine over epidural for prolonged postoperative analgesia in open abdominal surgery; extends randomized options beyond neuraxial routes.
RCT (n=130)
Single-blind
1:1 using a computerized software program
No
Does subcutaneous nalbuphine delay the time for the first postoperative analgesic request compared to epidural analgesia in adults undergoing open abdominal surgery?
Absolute Event Rate: 10.8% vs 3.29%
p-value: p=<0.001
Subcutaneous nalbuphine provides a longer duration of postoperative analgesia and reduces analgesic requirements compared to epidural analgesia in open abdominal surgeries, though with increased sedation.
Afify et al. (2023) conducted an RCT in Open abdominal surgery (n=130). Subcutaneous nalbuphine vs. Epidural analgesia (18 ml of bupivacaine 0.25% + 100 mcg fentanyl) was evaluated on Time for the first postoperative analgesic request after recovery (p=<0.001). Subcutaneous nalbuphine significantly prolonged the time to first postoperative analgesic request compared to epidural analgesia (10.8 vs 3.29 hours, p<0.001) in patients undergoing open abdominal surgery.
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