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September 28, 2025International Journal of Pharmaceutical Quality Assurance

Role of Epidural Nalbuphine as Adjuvant In Perioperative Pain Management in Lower Limb Surgeries

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Authors

SGSrishti GuptaAGAseem GargavaGYG. Yadav

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Overview

Prospective study shows nalbuphine significantly improves analgesia duration in lower limb surgeries, indicating effective perioperative pain management.

Key Points

  • Adding nalbuphine to bupivacaine provides significantly longer duration of analgesia compared to bupivacaine alone.
  • The time for sensory blockade onset is markedly reduced with nalbuphine, averaging 5.4 minutes compared to 15.95 minutes in control.
  • Motor blockade was achieved significantly faster in the nalbuphine group, with notable improvement in duration and effectiveness.
  • No significant side effects like respiratory depression were observed, indicating the safety of epidural nalbuphine for pain management.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/68d90bc641e1c178a14f6dcehttps://doi.org/10.25258/ijpqa.16.5.09
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Evaluation of Intrathecal Nalbuphine as an Adjuvant to Bupivacaine in Elective Cesarean Sections: A Randomized, Double-blind, Controlled Trial2025
  2. 2Assessment of the Efficacy of Nalbuphine as an Adjuvant to Intrathecal Bupivacaine in Endoscopic Urological Surgeries for the Prolongation of Postoperative Analgesia2024
  3. 3The analgesic efficacy of subcutaneous nalbuphine compared with epidural analgesia in abdominal surgeries: A randomized controlled trial2023
  4. 4A comparative study on the effect of intrathecal nalbuphine and buprenorphine as an adjuvant to 0.5% hyperbaric bupivacaine in elective infraumbilical surgeries2024 · 3 citations
  5. 5Comparison of nalbuphine and morphine as intrathecal adjuvant to 0.5% bupivacaine for post-operative analgesia in lower abdominal surgeries – A randomized and control study2024