Straightforward Synthesis of Chiral Hydroxy Isocyanides

Various types of hydroxy isocyanides have been prepared from the corresponding amino alcohols. These hydroxy isocyanides are interesting building blocks for multicomponent reactions and the synthesis of (hydroxyalkyl)oxazoline ligands. The isocyanides are susceptible to cyclization, giving rise to oxazolines. Therefore, they should be prepared freshly before use or be stored below –30 °C.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)