Key result
Increased Left Atrial Volume Index was significantly associated with the presence of diastolic dysfunction in hypertensive patients, occurring in 95.6% of those with increased LAVI compared to 31.3% with normal LAVI.
Why the study?
The study aimed to determine the prevalence of diastolic dysfunction in hypertensive patients and examine the association between Left Atrial Volume Index and the severity of diastolic dysfunction.
Is Left Atrial Volume Index associated with the severity of diastolic dysfunction in hypertensive patients?
Cross-Sectional (n=310)
No
Is Left Atrial Volume Index associated with the severity of diastolic dysfunction in hypertensive patients?
Absolute Event Rate: 95.6% vs 31.3%
p-value: p=<0.001
Increased Left Atrial Volume Index is significantly associated with the presence of diastolic dysfunction in hypertensive patients, serving as a potential prognostic marker.
May support LAVI as prognostic marker in hypertension; hypothesis-generating, needs prospective validation before practice change.
Objectives: The study aimed to determine the prevalence of diastolic dysfunction (DD) in hypertensive patients and to examine the association between the Left Atrial Volume Index (LAVI) and the severity of diastolic dysfunction in these patients. Methodology: This cross-sectional study was conducted at the Cardiology Department of CPEIC, Multan, from November 2, 2023, to May 31, 2024. A total of 310 hypertensive patients aged 30 to 70 years were enrolled. All participants underwent transthoracic and Doppler echocardiography to assess LAVI, diastolic dysfunction, and the severity of diastolic dysfunction (Grade I, II, or III), along with LAVI categorization (slightly, moderately, or grossly increased). Results: Among the 310 participants, the mean age was 48.48 ± 9.95 years, with 221 (71.29%) being male. Diastolic dysfunction was observed in 214 (69.03%) patients. Of the 214 with DD, 174 (95.6%) had an increased LAVI (p < 0.0001). In patients with normal LAVI, Grade I DD was observed in 18 (45%) patients, Grade II in 9 (22.5%), and Grade III in 13 (32.5%) patients. In contrast, among patients with increased LAVI, Grade I DD was present in 88 (50.6%) patients, Grade II in 57 (32.8%), and Grade III in 29 (16.7%) patients (p = 0.06). Conclusion: Diastolic dysfunction is prevalent in a significant proportion of hypertensive patients. The Left Atrial Volume Index (LAVI) is significantly associated with the presence and severity of diastolic dysfunction, highlighting its potential value in predicting the prognosis of hypertensive patients.
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Tauqeer et al. (2025) conducted a cross-sectional in Hypertension (n=310). Increased Left Atrial Volume Index (LAVI) vs. Normal LAVI was evaluated on Presence of diastolic dysfunction (p=<0.001). Increased Left Atrial Volume Index was significantly associated with the presence of diastolic dysfunction in hypertensive patients, occurring in 95.6% of those with increased LAVI compared to 31.3% with normal LAVI.
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