Left ventricular hypertrophy in patients with mild-to-moderate diastolic dysfunction was associated with significantly higher filling pressure (15.68 vs 14.07 mmHg, P<0.0001) and Tei index.
Cross-Sectional (n=450)
Does the presence of left ventricular hypertrophy worsen echocardiographic parameters of diastolic function in patients with mild-to-moderate left ventricular diastolic dysfunction?
In patients with mild-to-moderate left ventricular diastolic dysfunction, the presence of left ventricular hypertrophy is associated with worse diastolic parameters, suggesting it may be a predictor for progression to severe diastolic dysfunction.
Absolute Event Rate: 15.68% vs 14.07%
p-value: p=<0.0001
OBJECTIVES: Left ventricular diastolic dysfunction (LVDD) is associated with a variety of medical conditions. Left ventricular hypertrophy (LVH) is one of the most common abnormalities that induce LVDD. However, it is unclear whether LVH is a predictor of future LVDD deterioration that leads to diastolic heart failure in patients who already have mild-to-moderate LVDD. In this study, we investigated the effect of LVH on LV diastolic function in mild-to-moderate LVDD patients. METHODS: Of the patients with mild-to-moderate LVDD (Grade I and II) with preserved left ventricular ejection fraction (EF), 225 with LVH (LVH group) and 225 without LVH (non-LVH group) were consecutively selected. LVDD was defined by the abnormal patterns of Doppler mitral inflow and tissue Doppler. Left ventricular filling pressure (FP) was estimated by the following formula: 1.9 +1.24× early mitral inflow velocity (E)/early mitral annular velocity (e'). The Tei index was implemented to assess global (both systolic and diastolic) left ventricular function. Echocardiographic parameters for LVDD, such as isovolumic relaxation time (IVRT), were compared between the two groups. RESULTS: FP and Tei index were significantly higher in the LVH group compared to the non-LVH group 15.68 mmHg vs. 14.07 mmHg, P < 0.0001, and 0.58 vs. 0.53, P < 0.003, respectively. IVRT was significantly longer in the LVH group than in the non-LVH group 103.93 ± 23.93 vs. 95.94 ± 20.16, P < 0.0001. CONCLUSIONS: In mild-to-moderate LVDD patients, both FP and the Tei index were significantly higher when LVH was present. This may suggest LVH as a possible predictor for the future development of severe LVDD and diastolic heart failure.
Kattel et al. (Tue,) conducted a cross-sectional in Mild-to-moderate left ventricular diastolic dysfunction (n=450). Left ventricular hypertrophy vs. No left ventricular hypertrophy was evaluated on Left ventricular filling pressure (FP) (p=<0.0001). Left ventricular hypertrophy in patients with mild-to-moderate diastolic dysfunction was associated with significantly higher filling pressure (15.68 vs 14.07 mmHg, P<0.0001) and Tei index.