Key result
Worsening of diastolic function after percutaneous coronary intervention is independently associated with an increased risk of major adverse cardiac events.
Why the study?
Does worsening of diastolic function predict major adverse cardiac events in patients with coronary artery disease undergoing percutaneous coronary intervention?
Does worsening of diastolic function predict major adverse cardiac events in patients with coronary artery disease undergoing percutaneous coronary intervention?
Worsening of left ventricular diastolic function after PCI is an independent predictor of long-term major adverse cardiac events, highlighting the prognostic value of serial echocardiographic monitoring.
Several recent studies have demonstrated that the DD grade temporally changes in patients with preserved LV ejection fraction (LVEF).9-11 It has been shown that DD grade worsened in approximately one-fifth of a study population during the follow-up period and that worsening of diastolic function (DF) was associated with the development of HF and increased risk of death (Table ).10,11 Furthermore, Cavalcante et al 12 recently demonstrated that temporal changes in DF can predict clinical outcomes independently of LVEF recovery in patients with acute onset D iastolic dysfunction (DD) of the left ventricle is often found during comprehensive echocardiography, including tissue Doppler imaging, regardless of the presence or absence of heart failure (HF).1,2 The prevalence of DD increases with aging and is associated with coronary artery disease (CAD), hypertension, diabetes mellitus and left ventricular (LV) systolic dysfunction.3,4 The DD grade can be used for risk assessment in patients with heart disease.5-7 An advanced grade of DD (i.e., moderate (pseudonormal filling) or severe (restrictive filling)) is known to be associated with increased risk of death not only in patients with impaired systolic function but also in patients with normal systolic function.5,8
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Satoshi Yuda (2019) conducted an editorial in Coronary artery disease (n=1,235). Worsening of diastolic function vs. Improved or unchanged diastolic function was evaluated on Major adverse cardiac events (cardiac death, myocardial infarction, and repeat revascularization). Worsening of diastolic function after percutaneous coronary intervention is independently associated with an increased risk of major adverse cardiac events.
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