Key result
Hypertension without comorbidities is linked to LVDD in ~19% of patients, especially over age 60.
Why the study?
Left ventricular diastolic dysfunction is a key mechanism in the development of HFpEF in arterial hypertension, but structural and diastolic LV remodeling needed assessment in patients without comorbid conditions.
Observational (n=146)
No
In patients with arterial hypertension without comorbidities, early manifestations of left ventricular diastolic dysfunction are present in nearly 20% of patients and are associated with age and left ventricular hypertrophy.
May warrant diastolic assessment in older uncomplicated hypertensives; leaves open whether early detection alters HFpEF risk.
Objective: Left ventricular diastolic dysfunction (LVDD) is a key mechanism in the development of heart failure with preserved ejection fraction (HFpEF), particularly in patients with arterial hypertension. Objective is to assess the features of structural and diastolic remodeling of the left ventricle in patients with AH without concomitant comorbid conditions. Design and method: This prospective, descriptive, single-center study included 146 patients with AH and no cardiovascular diseases or conditions that could affect LV diastolic function. All participants underwent clinical and instrumental evaluation, including transthoracic echocardiography. Parameters assessed included LVEF, LVMI, LAVI, E/A ratio, tissue Doppler indices (e’, E/e’), and tricuspid regurgitation velocity. Results: All patients had normal LVEF. LVDD was identified in 19.2% of participants, more frequently in individuals >60 years. Age-related changes in LV filling were observed: E/A <0.8 was associated with elevated filling pressures and increased LVMI and LAVI. In patients with LV hypertrophy, more pronounced remodeling and impaired diastolic function (higher E/e’, prolonged isovolumetric relaxation) were documented. Patients with grade III hypertension demonstrated the most significant structural changes and pressures. No tricuspid regurgitation velocity >2.8 m/s was recorded. Conclusions: Arterial hypertension without comorbidities is associated with age-dependent changes in LV structure and diastolic function, indicating early manifestations of diastolic dysfunction. Regular echocardiographic monitoring is recommended to ensure timely detection of progressive myocardial remodeling.
No takes yet. Share an insight, caveat, or question.
Mukhtarkhanova et al. (2026) conducted an observational in Arterial hypertension (n=146). Arterial hypertension was evaluated on Left ventricular diastolic dysfunction (LVDD). Arterial hypertension without comorbidities was associated with left ventricular diastolic dysfunction in 19.2% of patients, occurring more frequently in individuals over 60 years of age.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: