Key result
A 20 mg bolus of tenecteplase administered after 70 minutes of unsuccessful cardiopulmonary resuscitation achieved return of spontaneous circulation within 2 minutes in a patient with massive pulmonary embolism.
Why the study?
Does low-dose tenecteplase improve return of spontaneous circulation in patients with cardiac arrest secondary to massive pulmonary embolism?
Case Report (n=1)
Does low-dose tenecteplase improve return of spontaneous circulation in patients with cardiac arrest secondary to massive pulmonary embolism?
A 20 mg bolus of tenecteplase may be effective in achieving return of spontaneous circulation during prolonged cardiopulmonary resuscitation for massive pulmonary embolism.
May support low-dose tenecteplase in refractory arrest from massive PE; hypothesis-generating and requires prospective validation.
The case of a 29 year-old man who suffered a cardiac arrest due to a massive pulmonary embolism while he was undergoing surgical repair of a complex tibial plateau fracture is presented. After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return of spontaneous circulation 2 min after administration of the drug. Pulmonary embolism was subsequently demonstrated on a pulmonary angiogram. To our knowledge this is the first report to show that the use of a low dose of tenecteplase might be useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive pulmonary embolism. Previously reported cases are reviewed.
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Hefer et al. (2007) conducted a case report in Cardiac arrest due to massive pulmonary embolism (n=1). Tenecteplase was evaluated on Return of spontaneous circulation. A 20 mg bolus of tenecteplase administered after 70 minutes of unsuccessful cardiopulmonary resuscitation achieved return of spontaneous circulation within 2 minutes in a patient with massive pulmonary embolism.
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