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September 8, 2015PLoS ONEOpen Access

Co-Circulation of the Rare CPV-2c with Unique Gln370Arg Substitution, New CPV-2b with Unique Thr440Ala Substitution, and New CPV-2a with High Prevalence and Variation in Heilongjiang Province, Northeast China

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Key result

CPV-2 testing detects ~47% positivity among dogs with diarrhea in northeast China across three variants.

  • n=201

Population

201 stool samples from dogs with diarrhea in Heilongjiang province of northeast China from May 2014 to April…

Design

Other

Authors

YGYufei GengDGDonghua GuoCLChunqiu Li

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Overview

Highlights need for regional CPV-2 surveillance in dogs; leaves open questions on vaccine efficacy against emerging variants.

Study Design

Type

Cross-Sectional (n=201)

Multicenter

Yes

Structured PICO

P
Population
201 dogs aged 1 month to 1 year with diarrhea from three districts in Heilongjiang province, China, evaluated for CPV-2 infection.
O
Outcome
Presence and genetic characterization of canine parvovirus-2 (CPV-2)

The study identifies the co-circulation and genetic variation of CPV-2 strains, including rare and new variants, in dogs in northeast China.

Limitations

  • The study was limited to three districts in Heilongjiang province, requiring more extensive epidemiological surveys for validation.
  • Further studies are needed to understand the relationship between specific amino acid substitutions and the severity of clinical symptoms.

Cite This Study

Geng et al. (2015) conducted a cross-sectional in Diarrhea (Canine parvovirus-2 infection) (n=201). Canine parvovirus-2 (CPV-2) infection was evaluated on CPV-2 positivity rate. Among 201 dogs with diarrhea in northeast China, 47.26% tested positive for CPV-2, revealing co-circulation of new CPV-2a (64.21%), new CPV-2b (21.05%), and rare CPV-2c (14.74%) variants.

synapsesocial.com/papers/6aa3a395aaaedccdac749629https://doi.org/10.1371/journal.pone.0137288
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