Key result
CAD with MI linked to ~19% lower peak early diastolic LV inflow velocity versus controls.
Why the study?
Does pulsed Doppler analysis reveal impaired left ventricular diastolic function in patients with coronary artery disease with and without myocardial infarction compared to normal subjects?
Population
74 subjects, including 20 patients with coronary artery disease without myocardial infarction, 33 patients…
Comparison
Pulsed Doppler analysis of transmitral flow… vs Age-matched normal subjects.
Design
Cross-sectional
Authors
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May signal post-MI diastolic impairment; leaves open Doppler's added diagnostic value in CAD.
Observational (n=74)
Does pulsed Doppler analysis reveal impaired left ventricular diastolic function in patients with coronary artery disease with and without myocardial infarction compared to normal subjects?
Absolute Event Rate: 48% vs 59%
p-value: p=<0.001
Pulsed Doppler analysis demonstrates that resting global left ventricular diastolic function is impaired in coronary artery disease patients with prior myocardial infarction, but remains normal in uncomplicated coronary artery disease.
Denef et al. (2017) conducted an observational in Coronary artery disease (n=74). Coronary artery disease with myocardial infarction (CAD-HMI) vs. Normal controls was evaluated on Peak early diastolic LV inflow velocity (peak E) (p=<0.001). Coronary artery disease with myocardial infarction was associated with significantly lower peak early diastolic LV inflow velocity compared to normal controls (48 vs 59 cm/s, p<0.001).
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