Key result
ESRD is linked to a reduced E/A ratio versus controls, independent of age and MR.
Why the study?
Does end-stage renal disease alter left-ventricular filling parameters compared to normal controls?
Observational (n=125)
Does end-stage renal disease alter left-ventricular filling parameters compared to normal controls?
Patients with end-stage renal disease on chronic dialysis exhibit abnormal left-ventricular diastolic filling patterns, which are independently influenced by age and mitral regurgitation.
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ESRD-linked E/A reductions should not yet change practice; hypothesis-generating for prospective outcome studies.
Mamby et al. (2017) conducted an observational in End-stage renal disease (n=125). End-stage renal disease on chronic dialysis vs. Normal control subjects with no evidence of cardiovascular disease was evaluated on Early-to-atrial flow velocity ratio. End-stage renal disease was associated with a reduced early-to-atrial flow velocity ratio compared to normal controls, with age and mitral regurgitation also having independent effects.
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