Key result
Surgical stress suppressed testosterone and oestradiol concentrations, resulting in a compensatory elevation of LH concentrations.
Why the study?
Does surgical stress alter the secretions of LH, FSH, testosterone, and oestradiol in male patients?
Observational (n=12)
Does surgical stress alter the secretions of LH, FSH, testosterone, and oestradiol in male patients?
Surgical stress suppresses testosterone and oestradiol concentrations, resulting in a compensatory elevation of LH.
Alerts clinicians to transient perioperative hormone shifts in men; hypothesis-generating for clinical impact and prospective validation.
The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second and fifth post-operative day respectively and remained suppressed. Serum FSH showed no significant change. Despite a post-operative decrease in sex hormone binding globulin (SHBG) binding capacity, non-SHBG bound T showed a decrease parallel to T. Multiple sampling studies showed that the secretions of LH were increased and that of T were decreased post-operatively. Following surgery, LH responses to LHRH were magnified, FSH and T responses showed no significant change when compared with the pre-operative responses. These data suggest that secretions of LH were increased during surgery. Following surgical stress, T and E2 concentrations were suppressed resulting in a compensatory elevation of LH concentrations.
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Wang et al. (1978) conducted an observational in Surgical stress (n=12). Surgical stress vs. Pre-operative baseline was evaluated on Secretions of LH, FSH, testosterone (T) and oestradiol (E2). Surgical stress suppressed testosterone and oestradiol concentrations, resulting in a compensatory elevation of LH concentrations.
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