What is the clinical evidence from this study?

Study design: Observational. Population: Surgical stress under general anesthesia (n=90). Intervention: Surgical stress under general anesthesia vs. Controls without surgery and anesthesia. Primary outcome: Serum LH levels.

What question did this study set out to answer?

To determine the effects of surgical stress under standardized general anesthesia on circulating gonadotropins and sex steroids across male and female patients.

January 1, 1976The Journal of Clinical Endocrinology & Metabolism

Influence of Surgical Stress Under General Anesthesia on Serum Gonadotropin Levels in Male and Female Patients

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Key result

Surgical stress under general anesthesia caused significant intraoperative increases in serum LH levels and decreases in testosterone in males, but no significant LH changes in females.

Why the study?

Does surgical stress under general anesthesia affect serum gonadotropin and testosterone levels in male and female patients?

Population

18 postmenopausal females, 15 menstruating females, and 17 males undergoing surgery; and a control group of…

Comparison

Surgical stress under general anesthesia vs Controls without surgery and anesthesia

Design

Cohort

Follow-up

7 days post-operative

Authors

TAToshihiro AonoThe University of Tokyo KKK KurachiHamamatsu University School of Medicine MMMariko MiyataTokyo Women's Medical University

Discussion

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Implication

May prompt sex-specific hormonal monitoring in males during surgery; leaves open outcome impact and need for prospective trials.

Key Points

To determine the effects of surgical stress under standardized general anesthesia on circulating gonadotropins and sex steroids across male and female patients.
Assessed serum LH in 18 postmenopausal females, 15 menstruating females, and 17 males undergoing surgery with thiopental, succinylcholine, nitrous oxide, oxygen, and halothane.
Measured serum FSH in female patients and testosterone in male patients across standardized intraoperative and postoperative time points.
Compared hormonal values against non-surgical controls comprising 15 postmenopausal females, 15 menstruating females, and 10 males sampled at identical time intervals.
Serum LH levels in male patients increased significantly at 30 minutes and 1 hour following anesthesia induction, whereas female patients showed no significant intraoperative LH increases.
Male patients exhibited significant intraoperative and postoperative declines in serum testosterone, whereas female FSH levels showed no significant intraoperative alterations.
LH levels decreased at 5–6 hours and 2 days post-anesthesia (reaching statistical significance only in postmenopausal females) before returning toward baseline by day 7, while control subjects showed no significant fluctuations.

Study Design

Type

Observational (n=90)

Structured PICO

Does surgical stress under general anesthesia affect serum gonadotropin and testosterone levels in male and female patients?

Population

90 male and female subjects (50 undergoing surgery under general anesthesia and 40 normal controls) evaluated for serum gonadotropin levels up to 7 days.

Exposure

Surgical stress under general anesthesia (nitrous oxide, oxygen and halothane following induction with thiopental and succinylcholine chloride)

Comparator

Controls without surgery and anesthesia

Outcome

Serum LH levelssurrogate

Surgical stress under general anesthesia induces a significant intraoperative increase in serum LH levels and a decrease in testosterone in males, but not in females.

Cite This Study

Aono et al. (1976) conducted an observational in Surgical stress under general anesthesia (n=90). Surgical stress under general anesthesia vs. Controls without surgery and anesthesia was evaluated on Serum LH levels. Surgical stress under general anesthesia caused significant intraoperative increases in serum LH levels and decreases in testosterone in males, but no significant LH changes in females.

synapsesocial.com/papers/6a9987bc951a91d49aaba57e https://doi.org/10.1210/jcem-42-1-144

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Influence of Surgical Stress Under General Anesthesia on Serum Gonadotropin Levels in Male and Female Patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Influence of Surgical Stress Under General Anesthesia on Serum Gonadotropin Levels in Male and Female Patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider