Key result
Oral midazolam beats clonidine and dexmedetomidine for easy parental separation and mask acceptance in children.
Why the study?
Do oral dexmedetomidine or oral clonidine improve sedation, anxiolysis, and mask acceptance compared to oral midazolam for premedication in pediatric surgical patients?
Population
90 children of either sex, age 4-12 years, American Society of Anesthesiologists Physical status I, posted…
Comparison
Oral dexmedetomidine 4 μg/kg body weight or oral… vs Oral midazolam 0.5 mg/kg body weight
Design
RCT, Randomly allocated to one of the three groups of thirty patients each…
Follow-up
Up to 60 minutes after premedication
Authors
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Supports oral midazolam preference for pediatric premedication; confirms superiority over alpha-2 agonists in RCTs.
RCT (n=90)
Double-blind
randomly allocated
No
Do oral dexmedetomidine or oral clonidine improve sedation, anxiolysis, and mask acceptance compared to oral midazolam for premedication in pediatric surgical patients?
Oral midazolam remains superior to oral clonidine and dexmedetomidine for pediatric premedication, providing faster sedation, better anxiolysis, and easier parental separation.
Agrawal et al. (2017) conducted an RCT in pediatric surgical patients (n=90). Oral midazolam vs. Oral dexmedetomidine (4 μg/kg) and oral clonidine (4 μg/kg) was evaluated on Sedation, anxiolysis, change in heart rate and blood pressure, behavior at separation from parents, and mask acceptance. Oral midazolam was superior to oral clonidine and dexmedetomidine, resulting in significantly more children with easy separation from parents (P=0.028) and excellent mask acceptance (P=0.012).
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