Key result
Clonidine lacks the majority of negative effects associated with midazolam and is associated with beneficial perioperative effects for paediatric premedication.
Why the study?
Does clonidine improve perioperative management and reduce side effects compared to benzodiazepines for premedication in children?
Does clonidine improve perioperative management and reduce side effects compared to benzodiazepines for premedication in children?
Clonidine is presented as a favorable alternative to midazolam for pediatric premedication, avoiding negative cognitive and behavioral side effects.
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May support clonidine over midazolam for pediatric premedication; hypothesis-generating and requires RCTs before practice change.
Bergendahl et al. (2005) conducted a review in Paediatric premedication for surgery. Clonidine vs. Benzodiazepines (midazolam) was evaluated. Clonidine lacks the majority of negative effects associated with midazolam and is associated with beneficial perioperative effects for paediatric premedication.
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