Key result
Endothelial dysfunction in vascular tone regulation is linked to hypertension, atherosclerosis, and diabetes.
Key points are not available for this paper at this time.
Design
Review
Endothelial-targeted strategies merit exploration in hypertension and diabetes; confirms established links but leaves open targeted trials.
Through the release of a variety of relaxing and contracting factors, including nitric oxide and endothelin-1, the endothelium exerts a complex paracrine influence on vascular smooth muscle cells. Dysfunction of these mechanisms for regulating tone may have relevance to various clinical entities, including hypertension, atherosclerosis, renal failure, and diabetes.
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John D. Conger (1994) studied this question. Endothelial dysfunction in the regulation of vascular tone via factors like nitric oxide and endothelin-1 is linked to clinical entities such as hypertension, atherosclerosis, and diabetes.
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