Is there a relationship between mean platelet volume and the severity of coronary ectasia?

BACKGROUND: Several authors described the cardiovascular changes as consequence of the pneumoperitoneum (Pnp) during laparoscopic procedures.Increases in heart rate, mean arterial pressure (MAP), systemic and pulmonary vascular resistances and a decrease in cardiac index have been described, but its effects on the cardiac performance are less known.We aimed to evaluate the cardiac effects of Pnp in a group of otherwise healthy subjects undergoing elective laparoscopic cholecystectomy. MATERİALS AND METHODS:We included 47 patients with American Society of Anesthesiologists (ASA) physical status I or II; age over 18 years undergoing elective laparoscopic intervention who successfully completed the surgery with no immediate apparent surgical complications.Specifically, the patients with known significant systemic or cardiopulmonary disease were excluded.Echocardiography recordings were carried out at the beginning of anesthesia and after induction of PnP and CO2 evacuation and a 24-h period postoperatively.Transthoracic echocardiography (TTE) examinations were performed with a 3.5-MHz transducer (Philips HD15).All echocardiographic measurements were carried out according to the criteria of the American Society of Ecocardiography.RESULTS: After the creation of Pnp, we found that MAP increased and stroke volume decreased.At he same time LVEDV significantly diminished (p=0.002).Significant variation was also found regarding the cardiac output (CO), HR and EF.We observed that capnoperitoneum led to a significant reduction of EF (from 62.5±3.5 to 59.5±2.7 %, p < 0.05).