Key result
Viruses modulate host and viral mRNA translation by selectively altering translation factors in infected cells.
Provides insights into how viruses modulate the host cell translation apparatus to optimize viral mRNA translation and replication.
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May inform antiviral drug design targeting translation; leaves open therapeutic translation in human infections.
Viruses have evolved a remarkable variety of strategies to modulate the host cell translation apparatus with the aim of optimizing viral mRNA translation and replication. Recent studies have revealed that modulation of both host and viral mRNA translation can be accomplished by selective alteration of translation factors in virus-infected cells. These findings provide new insights into the functioning of the translational apparatus in both uninfected and infected cells.
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Thompson et al. (2000) conducted a review in Viral infection. Viral infection was evaluated. Viruses modulate both host and viral mRNA translation by selectively altering translation factors in infected cells.
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