Novel piperazine and piperidine derivatives 8e and 9e show promise as potent inhibitors of EV71 and CVA16 with low cytotoxicity.
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No immediate clinical use; hypothesis-generating for these derivatives as enterovirus antivirals.
A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
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Zhang et al. (2013) studied this question.
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