Key result
Ventricular shear stress increases KLF2 and NOV expression and suppresses MCP-1 versus aortic waveforms.
Why the study?
Does the ventricular shear stress waveform alter gene expression in cultured human endothelial cells compared to the aortic waveform?
Does the ventricular shear stress waveform alter gene expression in cultured human endothelial cells compared to the aortic waveform?
p-value: p=<0.01
Distinct shear stress waveforms on opposing sides of the aortic valve leaflet evoke differential endothelial gene expression, suggesting a mechanotransduction mechanism for the side-specific localization of calcific aortic stenosis lesions.
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In vitro waveform-specific endothelial gene changes may underlie side-specific aortic stenosis; hypothesis-generating and requires in vivo validation.
Weinberg et al. (2010) studied Calcific aortic stenosis. Ventricular shear stress waveform vs. Aortic shear stress waveform was evaluated on Gene expression of KLF2, NOV, and MCP-1 (p=<0.01). Human endothelial cells subjected to the ventricular shear stress waveform showed significantly increased expression of KLF2 and NOV, and suppressed expression of MCP-1 compared to the aortic waveform (P<0.01).
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