Key result
Non-E3/3 genotype increased the odds of postprandial hypertriglyceridemia after a fat overload compared to E3/3 genotype in metabolic syndrome patients (OR 6.2; 95% CI 1.41-16.08; P=0.01).
Why the study?
Does the non-E3/3 apolipoprotein E genotype predict postprandial hypertriglyceridemia and hyperuricemia in patients with metabolic syndrome?
Population
66 patients with metabolic syndrome, none of whom had diabetes
Comparison
Non-E3/3 apolipoprotein E genotype vs E3/3 apolipoprotein E genotype
Design
Cross-sectional
Follow-up
4 hours
Authors
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Should not yet guide clinical decisions in metabolic syndrome; leaves open apoE genotyping's predictive utility pending prospective validation.
Observational (n=66)
Does the non-E3/3 apolipoprotein E genotype predict postprandial hypertriglyceridemia and hyperuricemia in patients with metabolic syndrome?
Odds Ratio: 6.2 (95% CI 1.41–16.08)
p-value: p=0.01
In patients with metabolic syndrome, the absence of the apo E3/3 genotype is a strong predictor of postprandial hypertriglyceridemia and hyperuricemia following a fat load.
Cardona et al. (2005) conducted an observational in Metabolic syndrome (n=66). Non-E3/3 genotype vs. E3/3 genotype was evaluated on Postprandial hypertriglyceridemia (OR 6.2, 95% CI 1.41-16.08, p=0.01). Non-E3/3 genotype increased the odds of postprandial hypertriglyceridemia after a fat overload compared to E3/3 genotype in metabolic syndrome patients (OR 6.2; 95% CI 1.41-16.08; P=0.01).
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