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The evaluation of efficient synthetic methods for the preparation of ( R )-2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethylpyrimidine, GW273225X ( 1 ), is described. The initial synthesis using ethylfluoroacetate was evaluated against three alternative routes using either nucleophilic fluorination, electrophilic fluorination, or sodium fluoroacetate.
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Walker et al. (2013) studied this question.
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