Key result
Low SBP is not associated with differences in neuropsychiatric scores versus higher SBP in dementia.
Why the study?
Neuropsychiatric symptoms are common in dementia and brain hypoperfusion may play a role, but the association between low systolic blood pressure, antihypertensive medication, and these symptoms remained unclear.
Does low systolic blood pressure or antihypertensive medication use affect neuropsychiatric symptoms in older people with dementia?
Population
412 older nursing home patients with dementia in Norway
Comparison
Lowest SBP quartile vs rest, and antihypertensive medication use vs non-use
Design
Cross-sectional baseline analysis of a multicenter cluster trial
Authors
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Low SBP shows no link to neuropsychiatric symptoms in dementia; leaves open antihypertensive effects on behavior in this population.
Cross-Sectional (n=412)
Yes
Does low systolic blood pressure or antihypertensive medication use affect neuropsychiatric symptoms in older people with dementia?
Mean Difference: -1.07
p-value: p=0.62
In older patients with dementia, neither low systolic blood pressure nor the use of antihypertensive medications was associated with an increase in neuropsychiatric symptoms.
Jong-Schmit et al. (2020) conducted a cross-sectional in Dementia (n=412). Low systolic blood pressure (lowest quartile) and antihypertensive medication vs. Higher systolic blood pressure and no antihypertensive medication was evaluated on Total Neuropsychiatric Inventory-Nursing Home version (NPI-NH) score (difference -1.07, p=0.62). Low systolic blood pressure was not associated with a difference in total Neuropsychiatric Inventory scores compared to higher SBP (difference -1.07, P=0.62) in older patients with dementia.
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