To Evaluate the Effect of Esmolol on Perioperative Analgesic Requirement in Patients Undergoing Laparoscopic Surgery Under General Anesthesia.

BACKGROUND: Esmolol is a short acting beta blocker. Esmolol is primarily used in the treatment of hypertension and tachycardia during anesthesia, but some study claim that it can be used to modulate pain. The main objective of this study was to evaluate the effect of esmolol on perioperative analgesic requirement in patients undergoing laparoscopic surgery. METHOD: It was a prospective, randomized, double blind interventional study. Total number of participants was 60. The study was carried out for a period of 3 years from 2015- 2017 in the department of Anesthesiology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Informed consent was taken from all the participants included in this study. RESULT: In Group E, 27/30 patients had VAS score ≤ 3 compared to 8/30 patients in the Group C at 15 minutes. Similarly at 30 minutes and next 24 hours, all of 30 patients in Group E had VAS score of≤ 3 compared to 18/30 patients in Group C. CONCLUSION: Esmolol decreases perioperative analgesic requirement and postoperative pain. The visual analogue score for pain assessment was found to be signicantly lower in the esmolol group.