Key result
Chemical cardioplegia linked to ~67% lower perioperative mortality versus normothermia during aortic valve replacement.
Why the study?
Does chemical cardioplegia reduce perioperative mortality compared to normothermia in patients undergoing aortic valve replacement?
Observational (n=127)
Does chemical cardioplegia reduce perioperative mortality compared to normothermia in patients undergoing aortic valve replacement?
The use of chemical cardioplegia for myocardial protection during aortic valve replacement is associated with a lower perioperative mortality rate compared to normothermia.
Answers are grounded in this paper and cite their sources.
May support chemical cardioplegia for myocardial protection in AVR; leaves open mortality benefit pending randomized confirmation.
In a 12-year period, 127 patients with isolated aortic valve disease underwent valve replacement surgery. Long-term results are presented in regard to patients with operation between 1967 and 1974 and immediate results in the later cases. The main conclusions from the study are that the type of myocardial protection is important for the perioperative mortality rate. This rate was 18% in patients operated on in normothermia and 6% in those with chemical cardioplegia. No significant correlation was found between preoperative NYHA grouping and mortality or complication rate, and the long-term result was independent of the type of valvular prosthesis.
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Vejlsted et al. (1984) conducted an observational in Isolated aortic valve disease (n=127). Chemical cardioplegia vs. Normothermia was evaluated on Perioperative mortality rate. Chemical cardioplegia was associated with a lower perioperative mortality rate (6%) compared to normothermia (18%) during aortic valve replacement surgery.
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