Key result
Insulin-dependent diabetes mellitus was associated with a significant rise in arterial wall stiffness, which correlated highly with increased arterial wall thickness.
Cross-Sectional (n=19)
Young patients with insulin-dependent diabetes exhibit increased arterial wall stiffness and thickness, indicating early diabetic macroangiopathy.
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May signal early macroangiopathy in young IDDM patients; leaves open prospective validation of stiffness as a clinical biomarker.
By means of ultrasonography, arterial wall stiffness, arterial wall thickness, and the elastic modulus of the common femoral artery were estimated in a group of 19 young insulin-dependent diabetics. The ultrasound technique for determination of these parameters is described as well as the echo-anatomy of the arterial wall. In accordance with a previous investigation a significant rise in arterial wall stiffness was found. Furthermore, there was a highly significant correlation between the stiffness and the thickness of the arterial wall. The elastic modulus also correlated to the stiffness. It is concluded that the diabetic macroangiopathy is characterized by an increased stiffness of the arterial wall caused by increased thickness as well as by progressive alterations of the elastic characteristics of the wall tissue. Possible pathogenetic reasons are discussed.
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Christensen et al. (1988) conducted a cross-sectional in Insulin-Dependent Diabetes Mellitus (n=19). Insulin-dependent diabetes mellitus was evaluated on Arterial wall stiffness, arterial wall thickness, and elastic modulus of the common femoral artery. Insulin-dependent diabetes mellitus was associated with a significant rise in arterial wall stiffness, which correlated highly with increased arterial wall thickness.
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