Key result
Propofol increases cardiac output by ~13% and improves RVEF versus isoflurane.
Why the study?
Does propofol improve right ventricular function compared to equipotent isoflurane in patients undergoing anaesthesia?
Population
10 patients undergoing anaesthesia
Comparison
Propofol at minimum infusion rate (MIR) vs Isoflurane at equivalent minimum alveolar…
Design
RCT, Randomly assigned first agent in a cross-over design
Authors
Loading...
Propofol may be favored over isoflurane for patients with right ventricular impairment; extends randomized comparisons of anaesthetic haemodynamics.
RCT (n=10)
Randomly assigned cross-over
Does propofol improve right ventricular function compared to equipotent isoflurane in patients undergoing anaesthesia?
Absolute Event Rate: 4.5% vs 4%
p-value: p=< 0.05
Propofol provides better right ventricular performance than equipotent isoflurane, suggesting it may be preferable for patients with impaired right ventricular function.
Boyd et al. (1994) conducted an RCT in Anaesthesia (n=10). Propofol vs. Isoflurane was evaluated on Cardiac output (l.min-1) (p=< 0.05). Propofol resulted in significantly higher cardiac output (4.5 vs 4.0 L/min) and right ventricular ejection fraction (39.4% vs 35.1%) compared to isoflurane (P<0.05).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: