Stereoselective synthesis of functionalized 1,2,3,4-tetrahydroisoquinolines (THIQs) via highly diastereoselective Ugi three-component reactions (U3CRs) with chiral 3,4-dihydroisoquinolines (DHIQs)

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A highly diastereoselective Ugi three-component reaction (U3CR) of chiral 3,4-dihydroisoquinolines has been developed to synthesize enantiopure 1,2,3,4-tetrahydroisoquinolines (THIQs).