Key result
ANP induces relative bradycardia in rats via reduced intrinsic heart rate and enhanced parasympathetic inhibition.
Why the study?
Does atrial natriuretic factor alter autonomic interactions in the control of heart rate in conscious rats?
Population
Conscious rats
Comparison
Synthetic 28-residue rat atrial natriuretic… vs Intravenous saline at 64 microL/min
Design
Preclinical
Authors
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Should not change clinical practice; extends rat models of ANP effects on heart rate but leaves open human translation.
Does atrial natriuretic factor alter autonomic interactions in the control of heart rate in conscious rats?
In conscious rats, atrial natriuretic factor induces bradycardia primarily by decreasing intrinsic heart rate and enhancing parasympathetic inhibition of presynaptic sympathetic activity.
Ackermann et al. (1988) studied Heart rate regulation. Synthetic 28-residue rat atrial natriuretic peptide (ANF) vs. i.v. saline at 64 microL/min was evaluated on Heart rate and autonomic influences. Administration of atrial natriuretic peptide in conscious rats produced relative bradycardia, predominantly due to a reduced intrinsic heart rate and enhanced parasympathetic inhibition.
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