What question did this study set out to answer?

The aim is to assess the impact of atrial natriuretic factor on cardiac performance and neurotransmitter release.

February 1, 1986Clinical and Experimental Pharmacology and Physiology

No Effect of Atrial Natriuretic Factor on Cardiac Rate, Force and Transmitter Release

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Why the study?

Does atrial natriuretic factor affect cardiac rate, force, and neurotransmitter release in guinea-pig isolated heart preparations?

Population

Guinea-pig isolated heart preparations

Comparison

Synthetic atrial natriuretic factor vs Baseline/absence of ANF

Design

Preclinical

Authors

MHMasao HiwatariInternational University of Health and Welfare KSKeisuke SatohThe Welding Institute JAJames A. AngusVascular / Pulmonary Vascular

Discussion

Member takes

Implication

ANF selectivity for vascular over cardiac effects holds in guinea-pig models; leaves open in vivo or human translation.

Key Points

The aim is to assess the impact of atrial natriuretic factor on cardiac performance and neurotransmitter release.
Examined effects of synthetic ANF (1-300 nmol/l) on guinea-pig isolated heart preparations.
Evaluated contractile force in electrically driven papillary muscles and spontaneous beating in right atria.
Measured neurotransmitter release from nerve endings in the isolated atrium.
ANF had no significant effect on contractile force or pulse period in atria.
Chronotropic effects of isoprenaline and bethanechol remained unchanged with ANF.
ANF effectively relaxed isolated aortic rings precontracted with noradrenaline (IC50 = 3 nmol/l) and potassium (IC50 = 24 nmol/l).

Structured PICO

Does atrial natriuretic factor affect cardiac rate, force, and neurotransmitter release in guinea-pig isolated heart preparations?

Population

Guinea-pig isolated heart preparations (papillary muscle, spontaneously beating right atria, isolated aortic rings)

Intervention

Synthetic atrial natriuretic factor (ANF, 1-300 nmol/l)

Comparator

Baseline/absence of ANF

Outcome

Cardiac rate, contractile force, and neurotransmitter releasesurrogate

ANF at vasorelaxant doses does not directly affect myocardial contractility, heart rate, or neurotransmitter release in isolated guinea-pig hearts.

Cite This Study

Hiwatari et al. (1986) studied this question.

synapsesocial.com/papers/6a7558fbb35e02fb1503471d https://doi.org/10.1111/j.1440-1681.1986.tb00331.x

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No Effect of Atrial Natriuretic Factor on Cardiac Rate, Force and Transmitter Release

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

No Effect of Atrial Natriuretic Factor on Cardiac Rate, Force and Transmitter Release

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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