Key result
In older adults without known heart disease, hypertension independently predicted coronary artery calcium progression (OR 2.11), whereas metabolic syndrome itself did not.
Why the study?
Does metabolic syndrome or its individual components predict coronary artery calcium progression in older adults without known heart disease?
Population
338 older community-dwelling men and women without known heart disease, mean age 67.6 years.
Comparison
Metabolic syndrome and its components vs Absence of metabolic syndrome or its components
Design
Cohort
Follow-up
average 4.5 years
Authors
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Hypertension may inform CAC monitoring in older adults without heart disease; leaves open whether metabolic syndrome adds value beyond its components.
Cohort (n=338)
No
Does metabolic syndrome or its individual components predict coronary artery calcium progression in older adults without known heart disease?
Odds Ratio: 2.11 (95% CI 1.33–3.3)
p-value: p=0.002
Individual risk factors like hypertension and fasting plasma glucose are better predictors of coronary artery calcium progression than the composite metabolic syndrome in older adults.
Kramer et al. (2008) conducted a cohort in Coronary Artery Calcium Progression (n=338). Metabolic syndrome and its components (hypertension, fasting plasma glucose) vs. Absence of metabolic syndrome or its components was evaluated on Coronary artery calcium (CAC) progression (increase in total CAC volume score ≥2.5 mm3) (OR 2.11, 95% CI 1.33-3.3, p=0.002). In older adults without known heart disease, hypertension independently predicted coronary artery calcium progression (OR 2.11), whereas metabolic syndrome itself did not.
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