Key result
Higher insulin resistance in type 1 diabetes is linked to ~146% greater carotid plaque prevalence.
Why the study?
Although insulin resistance is increasingly common in type 1 diabetes, its relationship with atherosclerosis has been scarcely studied.
Is insulin resistance associated with preclinical carotid atherosclerosis in patients with type 1 diabetes?
Observational (n=191)
Is insulin resistance associated with preclinical carotid atherosclerosis in patients with type 1 diabetes?
Absolute Event Rate: 49.1% vs 20%
p-value: p=0.001
In patients with type 1 diabetes, insulin resistance assessed by eGDR is independently associated with carotid plaque burden, suggesting its utility as a marker for cardiovascular risk.
May aid CV risk stratification in T1D via eGDR; leaves open whether targeting insulin resistance alters atherosclerosis progression.
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Pané et al. (2020) conducted an observational in Type 1 diabetes (n=191). Insulin resistance (assessed via eGDR) vs. Lower insulin resistance was evaluated on Carotid plaque prevalence (p=0.001). In patients with type 1 diabetes, higher insulin resistance assessed by eGDR was associated with greater carotid plaque prevalence (49.1% vs 20%, P=0.001) and burden.
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