Key result
Fractionation shows atrial specific granules contain little noradrenaline, refuting them as primary storage sites.
The findings do not support the hypothesis that specific granules in mammalian atrial muscle cells are a storage site for noradrenaline.
Answers are grounded in this paper and cite their sources.
Does not support atrial granules as noradrenaline storage in mammals; leaves open primary catecholamine compartments for further subcellular study.
Studies on the function of the specific granules present in mammalian atrial muscle cells have been directed mostly to the possible role of these particles as a storage site for catecholamines, particularly noradrenaline. The availability of a fractionation method previously described, which allows us to obtain a purified specific granule preparation, has made it possible to compare the pattern of sedimentation of atrial noradrenaline and adrenaline with that of the specific granules. It was found that, after fractionation, most of the atrial noradrenaline and adrenaline liberated during homogenization was present in the microsomal fraction and in the high speed supernatant. The crude specific granule fraction and the purified specific granule subfraction contained comparatively small amounts of noradrenaline. These findings do not support the view that the specific granules are a site of storage of noradrenaline.
No takes yet. Share an insight, caveat, or question.
DeBold et al. (1973) studied this question. Fractionation of mammalian atrial muscle cells was evaluated on Sedimentation pattern of atrial noradrenaline and adrenaline. Fractionation of mammalian atrial muscle cells revealed that specific granules contained comparatively small amounts of noradrenaline, not supporting them as a primary storage site.
Synapse has enriched 10 related papers. Consider them for comparative context: