Population
12 male Sprague-Dawley rats exposed to adrenal demedullation and chemical depletion of cardiac catecholamines
Design
Preclinical
Authors
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May support local cardiac adrenaline synthesis in animals; leaves open relevance to human HF or arrhythmias.
The study demonstrates that cardiac atria and ventricles contain distinct inducible adrenaline-synthesizing enzymes, indicating the heart can synthesize a significant portion of its own adrenaline.
Elayan et al. (1990) studied this question.
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