Adrenaline Release by the Human Heart
Why the study?
Do physiological stressors increase regional release of adrenaline and noradrenaline to plasma in humans?
Population
Humans
Comparison
Physiological stressors vs Rest
Authors
Discussion
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Member takes
Implication
Cardiac adrenaline release is detectable only during intense exercise; leaves open its physiological role in human stress responses.
Key Points
- To measure regional release rates of adrenaline and noradrenaline from the human heart at rest and during various sympathetic stimuli.
- Applied radiotracer dilution methods to quantify regional plasma adrenaline and noradrenaline spillover in human organs.
- Evaluated cardiac catecholamine release across baseline rest, mental stress, isometric exercise, and supine bicycle exercise.
- Cardiac adrenaline release was undetectable at rest and during mild cardiac sympathetic activation induced by mental challenge and isometric exercise.
- Supine bicycle exercise produced detectable cardiac adrenaline release averaging 1.63 ng/min alongside a 10- to 20-fold elevation in cardiac noradrenaline release to a mean of 128 ng/min.
Structured PICO
Do physiological stressors increase regional release of adrenaline and noradrenaline to plasma in humans?
P
Population
Humans
I
Intervention
Physiological stressors (mental challenge, isometric exercise, and supine bicycle exercise)
C
Comparator
Rest
O
Outcome
Rates of regional release of adrenaline and noradrenaline to plasmasurrogate
Cardiac adrenaline release in humans is undetectable at rest or during mild stress but becomes measurable during intense exercise.
Cite This Study
Esler et al. (1991) studied this question.