Key result
In anesthetized dogs, intracoronary tyramine and electrical sympathetic nerve stimulation caused marked increases in the output of radioactive noradrenaline from the heart.
Population
Anesthetized open-chest dogs
Comparison
Intracoronary injection of tritiated… vs Baseline/initial levels prior to stimulation
Design
Preclinical
Authors
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Validates canine heart preparation for sympathetic noradrenaline studies; leaves open translation to human cardiac function.
This in vivo dog heart preparation is sensitive enough to detect noradrenaline liberation following drug-induced and electrical sympathetic nerve stimulation, allowing for correlation with cardiac function parameters.
Yamaguchi et al. (1973) studied this question. Tritiated noradrenaline injection followed by tyramine or electrical stimulation was evaluated on Output of radioactivity from the heart. In anesthetized dogs, intracoronary tyramine and electrical sympathetic nerve stimulation caused marked increases in the output of radioactive noradrenaline from the heart.
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