January 1, 2012Journal of Atherosclerosis and ThrombosisOpen Access

Coexistence of Visceral Fat and Multiple Risk Factor Accumulations is Strongly Associated with Coronary Artery Disease in Japanese (The VACATION-J Study)

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Coronary Artery Disease (n=257). Intervention: Coexistence of visceral fat accumulation (≥100 cm2) and 3 cardiovascular risk factors vs. Visceral fat area 90% and/or severely calcified lesions) (OR 20.42, 95% CI 3.60-115.73, p=0.0007).

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Key result

Visceral fat accumulation plus three cardiovascular risk factors linked to ~20-fold higher CAD risk.

OR 20.42
95% CI 3.60-115.73
P=0.0007
n=257

Why the study?

Is the coexistence of visceral fat accumulation and multiple risk factors associated with an increased risk of coronary artery disease in Japanese patients?

Population

257 Japanese subjects with suspected coronary artery disease who underwent 64-row multislice computed…

Comparison

Visceral fat accumulation combined with multiple… vs VFA <100 cm² and 0 risk factors.

Design

Cross-sectional

Authors

AHAki Hiuge-ShimizuThe University of Osaka KKKen KishidaGeneral / Preventive / Lipids TFTohru FunahashiPreventive Cardiology

Discussion

Member takes

Overview

May inform risk stratification in Japanese patients; hypothesis-generating and requires prospective validation before practice change.

Study Design

Type

Cross-Sectional (n=257)

Multicenter

Yes

Structured PICO

Is the coexistence of visceral fat accumulation and multiple risk factors associated with an increased risk of coronary artery disease in Japanese patients?

Population

257 Japanese outpatients with suspected coronary artery disease who underwent multislice computed tomography coronary angiography and visceral fat area measurement.

Exposure

Visceral fat accumulation (VFA ≥100 cm²) combined with multiple risk factor accumulation (2 or 3 risk factors).

Comparator

VFA <100 cm² and 0 risk factors.

Outcome

Presence of coronary artery disease (CAD) assessed by CT coronary angiography.surrogate

Main Result

Odds Ratio: 20.42 (95% CI 3.6–115.73)

p-value: p=0.0007

The coexistence of visceral fat accumulation and multiple risk factors synergistically increases the risk of coronary artery disease in Japanese patients.

Limitations

MSCT coronary angiography is not the gold standard for the evaluation of CAD.
The study included a relatively small sample of 257 subjects, with only 91 diagnosed with CAD.
There is a need for separate studies of men and women, which would require a larger sample size.

Cite This Study

Hiuge-Shimizu et al. (2012) conducted a cross-sectional in Coronary Artery Disease (n=257). Coexistence of visceral fat accumulation (≥100 cm2) and 3 cardiovascular risk factors vs. Visceral fat area <100 cm2 and 0 risk factors was evaluated on Presence of coronary artery disease (atherosclerotic stenosis >90% and/or severely calcified lesions) (OR 20.42, 95% CI 3.60-115.73, p=0.0007). The coexistence of visceral fat accumulation (≥100 cm2) and 3 cardiovascular risk factors was strongly associated with coronary artery disease (OR 20.42).

synapsesocial.com/papers/6aa3eb70e0a56e090ff43833 https://doi.org/10.5551/jat.13037

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January 1, 2012Journal of Atherosclerosis and ThrombosisOpen Access

Coexistence of Visceral Fat and Multiple Risk Factor Accumulations is Strongly Associated with Coronary Artery Disease in Japanese (The VACATION-J Study)

View Full Paper

Ask AI

Bookmark

Key result

Visceral fat accumulation plus three cardiovascular risk factors linked to ~20-fold higher CAD risk.

OR 20.42
95% CI 3.60-115.73
P=0.0007
n=257

Why the study?

Is the coexistence of visceral fat accumulation and multiple risk factors associated with an increased risk of coronary artery disease in Japanese patients?

Population

257 Japanese subjects with suspected coronary artery disease who underwent 64-row multislice computed…

Comparison

Visceral fat accumulation combined with multiple… vs VFA <100 cm² and 0 risk factors.

Design

Cross-sectional

Authors

AHAki Hiuge-ShimizuThe University of Osaka KKKen KishidaGeneral / Preventive / Lipids TFTohru FunahashiPreventive Cardiology

Discussion

Member takes

Overview

May inform risk stratification in Japanese patients; hypothesis-generating and requires prospective validation before practice change.

Study Design

Type

Cross-Sectional (n=257)

Multicenter

Yes

Structured PICO

Is the coexistence of visceral fat accumulation and multiple risk factors associated with an increased risk of coronary artery disease in Japanese patients?

Population

257 Japanese outpatients with suspected coronary artery disease who underwent multislice computed tomography coronary angiography and visceral fat area measurement.

Exposure

Visceral fat accumulation (VFA ≥100 cm²) combined with multiple risk factor accumulation (2 or 3 risk factors).

Comparator

VFA <100 cm² and 0 risk factors.

Outcome

Presence of coronary artery disease (CAD) assessed by CT coronary angiography.surrogate

Main Result

Odds Ratio: 20.42 (95% CI 3.6–115.73)

p-value: p=0.0007

The coexistence of visceral fat accumulation and multiple risk factors synergistically increases the risk of coronary artery disease in Japanese patients.

Limitations

MSCT coronary angiography is not the gold standard for the evaluation of CAD.
The study included a relatively small sample of 257 subjects, with only 91 diagnosed with CAD.
There is a need for separate studies of men and women, which would require a larger sample size.

Cite This Study

synapsesocial.com/papers/6aa3eb70e0a56e090ff43833 https://doi.org/10.5551/jat.13037

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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