September 17, 2009Biology of the Neonate
Plasma Renin Activity in Sheep Pregnancy after Fetal or Maternal Nephrectomy
Key result
Bilateral fetal or maternal nephrectomy in pregnant sheep demonstrated that renin does not cross the placenta and that fetal plasma renin activity is independent of maternal levels.
Population
9 chronically catheterized pregnant Dorset sheep
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Does not alter clinical renin assessment in pregnancy; leaves open human placental transfer.
Structured PICO
P
Population
9 chronically catheterized pregnant Dorset sheep.
I
Intervention
Bilateral fetal or maternal nephrectomy, and intravenous furosemide
O
Outcome
Basal and diuretic-stimulated plasma renin activity (PRA)surrogate
This preclinical study demonstrates that renin does not cross the placenta in sheep, indicating independent regulation of fetal and maternal plasma renin activity.
Cite This Study
Oakes et al. (2009) studied Pregnancy (n=9). Bilateral fetal or maternal nephrectomy was evaluated on Basal and diuretic-stimulated plasma renin activity (PRA). Bilateral fetal or maternal nephrectomy in pregnant sheep demonstrated that renin does not cross the placenta and that fetal plasma renin activity is independent of maternal levels.