Key result
Cesarean delivery with labor linked to ~3-fold higher plasma renin activity versus cesarean without labor.
Why the study?
How does delivery method and the early postnatal period affect plasma renin activity in newborns?
Observational
How does delivery method and the early postnatal period affect plasma renin activity in newborns?
Plasma renin activity in newborns is stimulated by labor, decreases immediately postnatally, and is restimulated in the early newborn period.
Answers are grounded in this paper and cite their sources.
Labor exposure warrants consideration when interpreting neonatal PRA; leaves open effects on early hemodynamic adaptation.
Plasma renin activity (PRA) was studied during delivery in umbilical cord venous blood and serially in the first 48 hours of life. PRA after cesarean section without labor, 15.2 +/- 2.3 ng/ml/hr (mean and SEM), was less than after cesarean section with labor, 44.1 +/- 8.9 (P less than .02), and vaginal delivery, 34.7 +/- 4.3 (P less than .05). PRA decreased during the first 30 minutes after vaginal delivery from 34.7 +/- 4.3 ng/ml/hr to 19.3 +/- 3.5 (P less than .01); PRA subsequently increased by four hours of life to 38.6 +/- 6.7 mg/ml/hr (P less than .05) and remained elevated throughout the 48-hour study period. These data show that PRA is stimulated during labor, decreases postnatally, and is again restimulated in the early newborn period.
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Hadeed et al. (1984) conducted an observational in Newborns. Labor during delivery vs. Cesarean section without labor was evaluated on Plasma renin activity (PRA) (p=<0.02). Labor during delivery stimulated plasma renin activity, which was 44.1 ng/ml/hr after cesarean with labor versus 15.2 ng/ml/hr after cesarean without labor.
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